Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse. - Wikidata - awgldk - TriplyDB

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

http://www.wikidata.org/entity/Q47435856

about

Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin.Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6 Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2 Clinical, laboratory and molecular signs of immunodeficiency in patients with partial oculo-cutaneous albinism Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells Regulation of zebrafish hatching by tetraspanin cd63 BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes Eukaryotic cells and their cell bodies: Cell Theory revised T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects.Detailed analysis of gene expression during development of T cell lineages in the thymus.EBAG9 tempers lymphocyte killing activity.Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis.Dawning of the age of genomics for platelet granule disorders: improving insight, diagnosis and management.Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse.Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles.STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5 Shouts, whispers and the kiss of death: directional secretion in T cells Hermansky-Pudlak syndrome: the importance of molecular subtyping Cellular, molecular and clinical characterization of patients with Hermansky-Pudlak syndrome type 5.RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function.Perforin: more than just a pore-forming protein.Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2 Neutrophil elastase in cyclic and severe congenital neutropenia.Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease Translating cell biology in vitro to immunity in vivo.Mechanisms of protein delivery to melanosomes in pigment cells.Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells.Intermediate filaments and vesicular membrane traffic: the odd couple's first dance?The cell biology of Hermansky-Pudlak syndrome: recent advances.Adaptor protein-3: A key player in RBL-2H3 mast cell mediator release.Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

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P2860

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

http://www.wikidata.org/entity/Q47435856

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@en

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@nl

type

label

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@en

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@nl

prefLabel

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@en

Adaptor protein 3-dependent mi ...... to the immunological synapse.

@nl

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Nature Immunology

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Adaptor protein 3-dependent mi ...... to the immunological synapse.

@en

P2093

Anna Day

http://www.w3.org/2001/XMLSchema#string

E Graham Davies

http://www.w3.org/2001/XMLSchema#string

Emma Blott

http://www.w3.org/2001/XMLSchema#string

Giovanna Bossi

http://www.w3.org/2001/XMLSchema#string

Jane C Stinchcombe

http://www.w3.org/2001/XMLSchema#string

Richard H Clark

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Sarah Booth

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Terry Hamblin

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P2860

Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor

AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes

The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are components of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles

Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet

AP-3: an adaptor-like protein complex with ubiquitous expression.

Characterization of the adaptor-related protein complex, AP-3

A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3.

Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes

The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)

P304

1111-1120

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10.1038/NI1000

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P433

11

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4

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Gillian Griffiths

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2003-10-19T00:00:00Z

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14566336

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P921