AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
about
Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin.BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesisLocalization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 functionBLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organellesTransport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitinationFunctions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomesEpitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartmentBLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organellesHermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Puerto Rican patients with hypopigmentation and platelet storage-pool deficiencyRole of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomesMelanosomes--dark organelles enlighten endosomal membrane transportCargos and genes: insights into vesicular transport from inherited human diseaseMelanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.Nonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak syndrome type 2BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomesPhosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome trafficMolecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterationsSorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes.Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Rab7 is a critical mediator in vesicular transport of tyrosinase-related protein 1 in melanocytes.Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cellsRegulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function.Sorting out signals in fly endosomes.The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis.Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome.Melanocytic galectin-3 is associated with tyrosinase-related protein-1 and pigment biosynthesis.Multivesicular bodies and multivesicular endosomes: the "ins and outs" of endosomal traffic.Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.Hermansky-Pudlak syndrome: vesicle formation from yeast to man.Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo traffickingMurine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles.Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Mechanisms of protein delivery to melanosomes in pigment cells.Darkness descends with two Rabs.Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes
P2860
Q21284167-89264135-26D7-4F99-AA35-C8505F774BFAQ24302143-C216B227-A6F6-4142-A2DE-0EB2A97F090AQ24308858-C2EF91DC-B881-4993-9758-16FD5AEF141FQ24312002-D53C88C4-11F7-4562-8C65-5A8E716DCFB9Q24315003-D7B1A421-1E05-496D-8B73-ABF9D32CB3F4Q24318243-924330AD-41E1-461F-8EEC-A740F91A2949Q24323356-88410B2E-CB77-4F01-BB88-BF2E0B4C4978Q24337303-E6E05105-7C3A-48CD-83A0-3F47238D6F5EQ24337651-D8020B3C-9EE5-469C-8E45-14C86B7098BAQ24536114-E9A28796-AE6F-44B1-BF90-8A72CBD8E57AQ24548353-64C780C2-1AEC-43A4-9747-CECDCA3BFA5AQ24647195-D440DE3B-133B-4BF0-8E55-D79AB3503462Q24648345-45B118FD-A7D1-4573-BFEA-55524573AD29Q24675801-088A95B1-E77E-4C82-926A-42C58D785D35Q24685566-450B46BF-CAB3-4E46-8936-4486D76822ADQ27310758-EFDAC989-EC53-4814-BA85-CFE4E1A9B575Q28216578-79CDA8C1-B477-47BE-A434-E9095650C54AQ28513739-E1C88A4B-7B22-4303-AAA8-CEB982845491Q28583370-82ABD8CE-ADE5-46AA-99D0-693EDFF446C0Q28585860-FE30498B-6D07-479E-A31B-BAFB9F5F796AQ30370005-C8F108E1-443A-4F0B-A388-536BCE4FA15BQ33630685-E67EAABF-FDCA-49DF-9065-9B89F0D92236Q33829986-3A9CBF28-F7C6-4726-B821-519F9A710E62Q33901756-E08FA034-6912-4933-BF69-A40504A2D6F4Q34249792-FAC5182B-5170-47AC-A277-DCEAAE7C5730Q34391252-568DFEA5-95C4-490E-B165-BD67C5E3DBDDQ34485728-3D54F014-8433-476E-8EE4-7E9B4FBF6904Q34585561-EE494D18-3CB7-4C98-8DE9-43C11BC0E0F6Q34585581-B0477D6F-66F4-4962-8E70-5358DE017C3EQ34609301-2DB469D4-E350-41F2-9327-B7B745A8C4FFQ34718290-64BCAF4A-633D-418D-A374-474E43878985Q34745140-C111100B-BD36-41D5-B7F8-56C110BBE687Q34771899-23B02E85-A6BC-4A7C-8C11-1371ACF13C3BQ35009608-DE278D24-564D-4135-A990-AA06BE79CFC4Q35129447-79E6EB72-227D-47F5-98B2-215765BB171FQ35788427-FC06E099-BD66-46F6-B53D-39FEE5D37434Q35840841-F6B10AD5-3C94-4365-94ED-FC453BD99A95Q35936316-FF1AE147-1FFB-421F-88F1-2BC560E64394Q36119087-2B6EFA5D-E131-4DA6-9D56-F722AF13BD3DQ36119125-9FACF9C9-F140-4561-BA42-9B91E4B652C7
P2860
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@ast
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en-gb
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@nl
type
label
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@ast
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en-gb
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@nl
prefLabel
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@ast
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en-gb
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@nl
P2093
P2860
P356
P1476
AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
@en
P2093
P2860
P304
P356
10.1091/MBC.12.7.2075
P407
P577
2001-07-01T00:00:00Z