about
Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principlesDesigning Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2Structural basis for bivalent Smac-mimetics recognition in the IAP protein familyRecognition of Smac-mimetic compounds by the BIR domain of cIAP1Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-MimeticNF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathwayKinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescueTREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy.Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.The activator of apoptosis Smac-DIABLO acts as a tetramer in solutionA NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor.Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPsNovel neurofibromatosis type 2 mutation presenting with status epilepticus
P50
Q27652497-F5580EC3-92C4-41D3-860E-AADA8EE6DF65Q27652810-203FBCEF-E3AA-48EE-9B82-9F011516B09AQ27655218-F2A5E1C8-C839-4F21-B8ED-780919AF3C0BQ27665119-0C57AD09-FE2D-4676-9F84-95D937C4387AQ27675179-DDC19F67-0362-4017-9AD0-CF6FEF0FCE9FQ27697656-FD20431C-25F2-4C88-8931-BD352CB3CAC7Q28487971-DC35E18A-BAE8-4B31-B106-74775B3EEBF7Q38957343-2225C0A6-10B6-4B17-B8C4-E594D5D6221BQ39260309-1C53FDA1-19BA-4FDF-8BD8-6824622F57DFQ39822939-9BF9591B-A12D-4A2F-8D4B-42FC1EC61623Q41480658-3AFEC7DC-FDCB-457F-83AE-BA85063E13F3Q46806247-6BCDBCD9-418E-4CBA-A91A-D4DF4AF92BABQ47846951-223F8B85-3538-47FE-8EE3-22715D50B64DQ63436398-0218B539-C39A-4EFC-846E-B5E21E05670BQ87517274-D699DDB4-61E2-4816-B4D8-83F8030EBFC8
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Federica Cossu
@ast
Federica Cossu
@en
Federica Cossu
@es
Federica Cossu
@nl
Federica Cossu
@sl
type
label
Federica Cossu
@ast
Federica Cossu
@en
Federica Cossu
@es
Federica Cossu
@nl
Federica Cossu
@sl
prefLabel
Federica Cossu
@ast
Federica Cossu
@en
Federica Cossu
@es
Federica Cossu
@nl
Federica Cossu
@sl
P106
P21
P31
P496
0000-0001-9753-3572