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Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principlesDesigning Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2Structural basis for bivalent Smac-mimetics recognition in the IAP protein familyRapid synthesis of oligosaccharides using an anomeric fluorous silyl protecting group.Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids.Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist.A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids.Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibComputational design of novel peptidomimetic inhibitors of cadherin homophilic interactions.Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents.New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics.Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery.Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors.Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.4-Aminoproline-based arginine-glycine-aspartate integrin binders with exposed ligation points: practical in-solution synthesis, conjugation and binding affinity evaluation.Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies.Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.Regulation of HuR structure and function by dihydrotanshinone-I.Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents.Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: SynthesisSynthesis of the Lewis a trisaccharide based on an anomeric silyl fluorous tagFroc: a new fluorous protective group for peptide and oligosaccharide synthesis
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Leonardo Manzoni
@ast
Leonardo Manzoni
@en
Leonardo Manzoni
@es
Leonardo Manzoni
@nl
Leonardo Manzoni
@sl
type
label
Leonardo Manzoni
@ast
Leonardo Manzoni
@en
Leonardo Manzoni
@es
Leonardo Manzoni
@nl
Leonardo Manzoni
@sl
prefLabel
Leonardo Manzoni
@ast
Leonardo Manzoni
@en
Leonardo Manzoni
@es
Leonardo Manzoni
@nl
Leonardo Manzoni
@sl
P1053
G-1280-2010
P106
P21
P31
P3829
P496
0000-0002-2056-8459