The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. - Wikidata - awgldk - TriplyDB

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis.Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan.Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer's disease mouse model 5xFAD.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer.Differential contribution of microglia and monocytes in neurodegenerative diseases.Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.Neurodegenerative signature.Neuroinflammation: Microglia and T Cells Get Ready to Tango.Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.ApoE facilitates the microglial response to amyloid plaque pathology.Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer.TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2R47H on murine myeloid cell function.The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson's Disease?Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function.Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency.A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.Automated Morphological Analysis of Microglia After Stroke.Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels.Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury Microglia in Alzheimer's disease Commentary: Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus Epothilone B Benefits Nigral Dopaminergic Neurons by Attenuating Microglia Activation in the 6-Hydroxydopamine Lesion Mouse Model of Parkinson's Disease Microglia in Alzheimer's Disease: A Role for Ion Channels

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

http://www.wikidata.org/entity/Q47568641

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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name

The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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type

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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J.IMMUNI.2017.08.008

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The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.

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Anna Worthmann

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Asaf Madi

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Bogdan Budnik

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Caroline Baufeld

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Charlotte Madore

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Cynthia Lemere

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David J Greco

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Elaine O'Loughlin

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Emily Tjon

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Fargol Mazaheri

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P2860

TREM2 Variants in Alzheimer's Disease

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

The M1 and M2 paradigm of macrophage activation: time for reassessment

Programmed cell death in animal development

Onset and progression in inherited ALS determined by motor neurons and microglia

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Christian Haass

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Rachid El Fatimy

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28930663

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neurodegeneration

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5719893

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