Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.
about
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.HEF1-dependent Aurora A activation induces disassembly of the primary ciliumTau and tauopathiesMaintenance of synaptic stability requires calcium-independent phospholipase A₂ activityRegulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding proteinThe RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau proteinThe EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent mannerEarly growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brainMutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunitPhosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cellsThe amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells).Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.PTL-1 regulates neuronal integrity and lifespan in C. elegans.Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis inductionDeactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.Genetic modifiers of tauopathy in Drosophila.C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanomaGenetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)tau kinases in the rat heat shock model: possible implications for Alzheimer disease.Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferasesDifferential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex.The role of tau in neurodegenerationAxonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.Transport and diffusion of Tau protein in neurons.Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits.P70 S6 kinase mediates tau phosphorylation and synthesis.Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices.Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress.Structure of the human glycogen-associated protein phosphatase 1 regulatory subunit hGM: homology modeling revealed an (alpha/beta)8-barrel-like fold in the multidomain protein.Yeast as a model system to study tau biology.Abundant expression of the microtubule-associated protein, ensconsin (E-MAP-115), alters the cellular response to Taxol.A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain.Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules.M20, the small subunit of PP1M, binds to microtubules.Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.
P2860
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P2860
Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@en
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@nl
type
label
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@en
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@nl
prefLabel
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@en
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@nl
P2093
P356
P1476
Protein phosphatase 1 is targe ...... tubule-associated protein Tau.
@en
P2093
P304
21901-21908
P356
10.1074/JBC.273.34.21901
P407
P577
1998-08-01T00:00:00Z