Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
about
Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.The study of genetic polymorphisms related to serotonin in Alzheimer's disease: a new perspective in a heterogenic disorder.APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population.Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease.Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.The complex interaction between APOE promoter and AD: an Italian case-control studyHapScope: a software system for automated and visual analysis of functionally annotated haplotypes.The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease.Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?Normal tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms.Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice.Molecular genetics of late-onset Alzheimer's disease.Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptidesEffects of APOE promoter polymorphism on the topological organization of brain structural connectome in nondemented elderlyApolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's diseaseApolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.Transcriptional regulation and its misregulation in Alzheimer's disease.Association between ε2/3/4, promoter polymorphism (-491A/T, -427T/C, and -219T/G) at the apolipoprotein E gene, and mental retardation in children from an iodine deficiency area, China.Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer.New ovine PrP gene haplotypes as a result of single nucleotide polymorphisms in the PrP gene promoter.Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.Genetic studies in Alzheimer's disease.Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population.Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume?Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease.Association between polymorphisms in the promoter region of the apolipoprotein E (APOE) gene and Alzheimer's disease: A meta-analysis.Discrepancies between apolipoprotein E phenotyping and genotyping in the elderly.Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study.ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain.Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms.APOE-epsilon4 and APOE -491A polymorphisms in individuals with subjective memory loss.TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E.
P2860
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P2860
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@en
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@nl
type
label
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@en
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@nl
prefLabel
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@en
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@nl
P2093
P356
P1476
Pronounced impact of Th1/E47cs ...... eveloping Alzheimer's disease.
@en
P2093
Chartier-Harlin MC
Delacourte A
P304
P356
10.1093/HMG/7.9.1511
P577
1998-09-01T00:00:00Z