Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease - Wikidata - awgldk - TriplyDB

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q36784564

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Alzheimer mechanisms and therapeutic strategies Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies Amyloids: friend or foe?Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?Oxidized cholesterol as the driving force behind the development of Alzheimer's disease Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.Alzheimer disease models and human neuropathology: similarities and differences Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors.Apolipoprotein E: a major piece in the Alzheimer's disease puzzle.Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.Use of genetic variation as biomarkers for Alzheimer's disease.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.Transgenic models of Alzheimer's disease: learning from animals The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.Why AMD is a disease of ageing and not of development: mechanisms and insights.Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo.Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.Molecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis.Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.Frontiers in the pathogenesis of Alzheimer's disease.Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis.The role of apolipoprotein E in Alzheimer's disease.

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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Apolipoprotein E is essential ...... e model of Alzheimer's disease

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B Ghetti

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R C Dodel

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

Isoform-specific binding of apolipoprotein E to beta-amyloid

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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