Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells.
about
Target identification by image analysisPretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapyCharacteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi ArabiaTotal synthesis of (-)-CP2-disorazole C1.Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolidesMitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.Fusarisetins: Structure-function studies on a novel class of cell migration inhibitorsIdentifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.Proteomic changes in the rat brain induced by homogenous irradiation and by the bystander effect resulting from high energy synchrotron X-ray microbeams.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents.Microtubule binding and disruption and induction of premature senescence by disorazole C(1).Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy.The synthesis of novel disorazoles.Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.
P2860
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P2860
Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@en
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@nl
type
label
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@en
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@nl
prefLabel
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@en
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@nl
P2093
P1476
Disorazol A1, a highly effecti ...... apoptosis in mammalian cells.
@en
P2093
Florenz Sasse
Hans Reichenbach
Yasser A Elnakady
P304
P356
10.1016/J.BCP.2003.10.029
P407
P577
2004-03-01T00:00:00Z