about
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterMICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityCa(2+) transfer from the ER to mitochondria: when, how and whyStructure and function of the mitochondrial calcium uniporter complexThe m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in MitochondriaThe mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitThe mitochondrial calcium uniporter controls skeletal muscle trophism in vivo.VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentationMitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase.Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.Structural and functional link between the mitochondrial network and the endoplasmic reticulum.The mitochondrial Ca(2+) uniporter.Mitochondria as sensors and regulators of calcium signalling.Enjoy the Trip: Calcium in Mitochondria Back and Forth.Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?Measuring baseline Ca(2+) levels in subcellular compartments using genetically engineered fluorescent indicators.Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production.Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux.Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.The MCU complex in cell death.Mitochondrial Calcium Handling in Physiology and Disease.Breast Tissue Engineering: Decellularized Scaffolds Derived from Porcine Mammary Glands.Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism.Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and HumansMFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergeticsLoss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference.DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass.MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.Molecular control of mitochondrial calcium uptakeA High-Throughput Screening Identifies MICU1 Targeting CompoundsTau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handlingOverexpression of Mitochondrial Calcium Uniporter Causes Neuronal DeathIdentification of an ATP-sensitive potassium channel in mitochondria
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Diego De Stefani
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Diego De Stefani
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Diego De Stefani
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Diego De Stefani
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Diego De Stefani
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type
label
Diego De Stefani
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Diego De Stefani
@en
Diego De Stefani
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Diego De Stefani
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Diego De Stefani
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prefLabel
Diego De Stefani
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Diego De Stefani
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Diego De Stefani
@es
Diego De Stefani
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Diego De Stefani
@sl
P1053
I-7715-2015
P106
P1153
23472903200
56079901000
P1960
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P21
P2798
P31
P3829
P3835
diego-de-stefani
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P569
2000-01-01T00:00:00Z