Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.
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Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factorsConserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucoseImpaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start sitePancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas developmentExtended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate dietTranscription factor regulation of pancreatic organogenesis, differentiation and maturationPcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceFoxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releaseTargeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.Genomic organisation of the seven ParaHox genes of coelacanthsA feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cellsDissecting the transcriptional network of pancreatic islets during development and differentiation.Sox9-haploinsufficiency causes glucose intolerance in miceGlial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3betaPancreas duodenal homeobox-1 expression and significance in pancreatic cancerIslet-1 Is essential for pancreatic β-cell function.Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Pdx1 restores beta cell function in Irs2 knockout mice.Role of Foxa-2 in adipocyte metabolism and differentiationGenomic profiling guides the choice of molecular targeted therapy of pancreatic cancer.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell functionPtf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.GATA4 and GATA6 control mouse pancreas organogenesis.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genesEarly Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitroOn the origin of the beta cell.The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation.MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells
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P2860
Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
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name
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@en
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@nl
type
label
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@en
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@nl
prefLabel
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@en
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@nl
P2093
P2860
P356
P1476
Pancreatic beta cell-specific ...... ic nuclear factor 3beta sites.
@en
P2093
Henderson E
P2860
P304
P356
10.1074/JBC.275.5.3485
P407
P577
2000-02-01T00:00:00Z