HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.
about
The HTLV-1 Tax interactomeHighlights on distinctive structural and functional properties of HTLV Tax proteinsAnalysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activityVanadate induction of NF-kB involves IkB kinase B and SAPK/ERK kinasa 1 in macrophagesvCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgammaDirect activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunitCoordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseIkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activitySignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainPseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-UMEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaThe zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABINRole of Tax protein in human T-cell leukemia virus type-I leukemogenicityMolecular Studies of HTLV-1 Replication: An UpdateControversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects?HTLV-1/-2 and HIV-1 co-infections: retroviral interference on host immune statusA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expressionMitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-betaActivation of IKKalpha and IKKbeta through their fusion with HTLV-I tax proteinRole of IKKgamma/nemo in assembly of the Ikappa B kinase complexProtein profile of tax-associated complexesProtein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activityIkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylationHTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsAll three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complexp115 Rho GTPase activating protein interacts with MEKK1.Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets.Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.Signal transduction and transcription factors in rheumatic disease.Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex.Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease.Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancersDirect association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
P2860
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P2860
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@en
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@nl
type
label
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@en
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@nl
prefLabel
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@en
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@nl
P2093
P1433
P1476
HTLV-I Tax protein binds to ME ...... vity and NF-kappaB activation.
@en
P2093
F Mercurio
L B Christerson
R B Gaynor
Y Yamamoto
P304
P356
10.1016/S0092-8674(00)81447-6
P407
P577
1998-05-01T00:00:00Z