Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.
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A Helicobacter pylori TolC efflux pump confers resistance to metronidazoleDirect detection of methylation in genomic DNABiological degradation of 2,4,6-trinitrotolueneDrug targets and mechanisms of resistance in the anaerobic protozoaNitroimidazoles for the treatment of TB: past, present and futureHigh-resolution structure of the antibiotic resistance protein NimA fromDeinococcus radioduransStructure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pyloriEnzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reductionIdentification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.Esterase mutation is a mechanism of resistance to antimalarial compoundsStructural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.Primary Antibiotic Resistance of Helicobacter pylori in China.Response to metronidazole and oxidative stress is mediated through homeostatic regulator HsrA (HP1043) in Helicobacter pylori.Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesisCharacterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.Antisense RNA modulation of alkyl hydroperoxide reductase levels in Helicobacter pylori correlates with organic peroxide toxicity but not infectivity.Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophilaThe Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosaIdentification of virulence genes of Helicobacter pylori by random insertion mutagenesisIdentification of environmental stress-regulated genes in Helicobacter pylori by a lacZ reporter gene fusion system.Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expressioncomH, a novel gene essential for natural transformation of Helicobacter pylori.Characterization of an acidic-pH-inducible stress protein (hsp70), a putative sulfatide binding adhesin, from Helicobacter pylori.Molecular characterization of benzimidazole resistance in Helicobacter pylori.Role of AmiA in the morphological transition of Helicobacter pylori and in immune escapeTreatment of Helicobacter pylori infection: current status and future concepts.Metabolism and genetics of Helicobacter pylori: the genome era.Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance.Why metronidazole is active against both bacteria and parasites.Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistanceReview article: nitroimidazole resistance in Helicobacter pylori.In vitro antimicrobial susceptibility testing of Helicobacter felis, H. bizzozeronii, and H. salomonis.Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in miceInsertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637.Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 studyAnalysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori.
P2860
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P2860
Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Metronidazole resistance in He ...... ensitive NADPH nitroreductase.
@en
Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene
@nl
type
label
Metronidazole resistance in He ...... ensitive NADPH nitroreductase.
@en
Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene
@nl
prefLabel
Metronidazole resistance in He ...... ensitive NADPH nitroreductase.
@en
Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene
@nl
P2093
P2860
P1476
Metronidazole resistance in He ...... ensitive NADPH nitroreductase.
@en
P2093
Hoffman PS
Kersulyte D
Veldhuyzen van Zanten SJ
P2860
P304
P356
10.1046/J.1365-2958.1998.00806.X
P407
P577
1998-04-01T00:00:00Z