Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.
about
Protein phosphatase 2A dysfunction in Alzheimer's diseasePhosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkProtein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingThe effects of aging on gene expression in the hypothalamus and cortex of miceProtein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complexCyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrestTemperature and toxic Tau in Alzheimer's disease: new insightsTau and tauopathiesStructure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau DephosphorylationTau Biology and Tau-Directed Therapies for Alzheimer's DiseaseRegulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndromeCHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survivalCytosolic Arl2 is complexed with cofactor D and protein phosphatase 2ACyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrestPhosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau proteinI1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2AReduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutationsActivation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytesAmyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction.Cytoskeletal pathologies of Alzheimer diseaseMice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.PP2A and GSK-3beta act antagonistically to regulate active zone developmentA novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers.Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease modelsStructure and pathology of tau protein in Alzheimer disease.From Alzheimer to Huntington: why is a structural understanding so difficult?Genetic modifiers of tauopathy in Drosophila.Mechanism of the process formation; podocytes vs. neurons.Phosphoproteomic profiling of selenate-treated Alzheimer's disease model cells.Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic targetAn axonemal PP2A B-subunit is required for PP2A localization and flagellar motility.Advances in tau-based drug discovery.Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degenerationThe Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells.
P2860
Q21090465-D8733683-6F9D-4279-9B69-7C99F2E59EB6Q21131229-928A0E45-D96F-47DA-86AF-783BD327D675Q24301939-C4C11CDF-A683-4100-AD23-919702BA8471Q24317775-9313862B-3519-4C95-9010-96AF8248D589Q24532278-6EA7E328-E655-4AC9-9999-80B8DCA242BEQ24614521-7234911D-1A82-4198-A907-A837D94970C4Q24673684-5FBF4E85-418E-47BC-8FEB-F94118968693Q24675495-27E3CA28-A407-4870-A93E-D52B960CF068Q26745778-3854103A-EE07-466C-AA8C-F8BB24007C0BQ27027415-F9FF3905-3380-47F3-A6E5-0056C1E3FDF6Q27652517-FFCAB3E2-81A9-438C-AD9C-C79C7F421385Q28071398-1B745A62-0B35-4E93-B1FD-03DC1E66F282Q28142893-512E8CF7-0720-4CD5-AB8F-C875BABFFE76Q28178021-9370DA58-3DA7-4F62-8667-C6172BC0F958Q28183470-9928EA67-C57D-43EE-8B7B-7EF82F2DAACCQ28200942-8BE13633-F3CB-41FD-A9BD-EBDD4253858BQ28214848-71D853F9-2946-4BCF-809A-B5E9BD91F30AQ28344418-56EF2171-8332-476F-A86E-EE2929E3431CQ28566668-A03FD9AB-CEB8-4AA2-A465-DA138E6A9A66Q28577828-FC3A9D7C-D021-4FE7-80EC-9DF1D12364AAQ28578658-B51999C3-DA94-4C39-9F69-CACEBF7F9B63Q30414554-FDF7BE72-E921-4C89-ADD7-9ECA0AF20460Q30419477-2A7A6D66-8DB5-42D3-8CE1-F2DB3B0D374CQ30435267-D52140C5-5268-460E-A476-7DE92FC1ECDBQ30473576-96104E59-0C6C-497D-BABC-53631618BF5FQ30544640-2CF45F0D-372F-4109-B1B5-A9D505150C55Q33503992-CB1A4991-E4B8-4AD3-8EBD-A9DB3387BF47Q33856559-CC27B5DA-D854-4CF0-9D1B-DC0CA256B568Q33952539-F582B5E1-CC85-46F0-B899-52CD3500DC04Q34068459-B790153F-335B-4A99-84F6-2BCBF2435728Q34280787-3338097B-4ABC-4711-B6C6-D5EE6CDA8876Q34463697-6FAAA7E0-C66E-4133-872D-BE30EDBCCF5BQ34619083-779B6A7A-4C34-4197-9DA6-9AECFC04A0E6Q34638702-6A8AE1BC-ABCB-48A4-B265-1F5C78A2F1C5Q34653771-8CD6DD56-4C0E-4B9A-80F9-98BBD9ADB2B7Q35016882-A96E98D7-90C7-4BF2-93F2-74091E0F27C7Q35153262-FFC74585-D41A-4852-B505-8CD90F4213B5Q35321539-92789E56-2622-4566-928F-7DBA75B1AC14Q35327851-5635B2BD-C973-4958-A1A4-9705FB07C444Q35712546-54E7B9DD-2F0F-48C1-9CD9-07967451694A
P2860
Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Molecular interactions among p ...... he development of tauopathies.
@en
Molecular interactions among p ...... he development of tauopathies.
@nl
type
label
Molecular interactions among p ...... he development of tauopathies.
@en
Molecular interactions among p ...... he development of tauopathies.
@nl
prefLabel
Molecular interactions among p ...... he development of tauopathies.
@en
Molecular interactions among p ...... he development of tauopathies.
@nl
P2093
P2860
P356
P1476
Molecular interactions among p ...... he development of tauopathies.
@en
P2093
Kamibayashi C
Nunbhakdi-Craig V
White CL 3rd
P2860
P304
25490-25498
P356
10.1074/JBC.274.36.25490
P407
P577
1999-09-01T00:00:00Z