Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures.
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Prion protein attenuates excitotoxicity by inhibiting NMDA receptorsImmunopurification of pathological prion protein aggregatesComment on: Neurotoxicity of prion peptide 106-126 not confirmed, by Beat Kunz, Erika Sandmeier, Philipp Christen. FEBS Letters 485 (1999) 65-68.Microglia and prion disease.Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity.MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie.A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.The elusive role of the prion protein and the mechanism of toxicity in prion disease.Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicityLate treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals.Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.Prions can infect primary cultured neurons and astrocytes and promote neuronal cell deathAntibody-based immunotherapeutic attempts in experimental animal models of prion diseases.Physiological Functions of the Cellular Prion Protein.Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.Cellular prion protein protects from inflammatory and neuropathic pain.Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes.Cerebellar compartmentation of prion pathogenesis.Resistance of cell lines to prion toxicity aided by phospho-ERK expression.Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects.Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells.Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.Prion-associated increases in Src-family kinases.Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line.The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3Species barrier in prion diseases: a kinetic interpretation based on the conformational adaptation of the prion protein.Activation effects of a prion protein fragment [PrP-(106-126)] on human leucocytes.Prion protein aggregation and neurotoxicity in cortical neurons.Reversibility of scrapie-associated prion protein aggregation.Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.Expression of excitatory amino acid transporter-1 (EAAT-1) in brain macrophages and microglia of patients with prion diseases.Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro.Prion protein peptide neurotoxicity can be mediated by astrocytes.Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment.Prions activate a p38 MAPK synaptotoxic signaling pathwayPrion acute synaptotoxicity is largely driven by protease-resistant PrPSc species
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P2860
Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Cytoprotective effect of NMDA ...... in rat cortical cell cultures.
@en
Cytoprotective effect of NMDA receptor antagonists on prion protein
@nl
type
label
Cytoprotective effect of NMDA ...... in rat cortical cell cultures.
@en
Cytoprotective effect of NMDA receptor antagonists on prion protein
@nl
prefLabel
Cytoprotective effect of NMDA ...... in rat cortical cell cultures.
@en
Cytoprotective effect of NMDA receptor antagonists on prion protein
@nl
P2093
P1476
Cytoprotective effect of NMDA ...... in rat cortical cell cultures.
@en
P2093
Forrest JM
Heffner-Lauc M
Schatton WF
Schröder HC
Ushijima H
P304
P356
10.1016/0922-4106(93)90040-G
P407
P577
1993-08-01T00:00:00Z