Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.
about
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statinsModulation of osteoclast differentiation and bone resorption by Rho GTPasesStructural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesisBisphosphonates: from bench to bedsideIsoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysisPamidronate improves the quality of life and induces clinical remission of bone metastases in patients with thyroid cancerAnti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines.Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast qualityThe pharmacology of bisphosphonates and new insights into their mechanisms of action.The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Intracellular membrane trafficking in bone resorbing osteoclasts.Farnesyl diphosphate synthase: a novel genotype association with bone mineral density in elderly women.Drug-induced glomerulopathies.Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats.Osteoporosis - a current view of pharmacological prevention and treatmentHow to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.Modulation of murine bone marrow-derived CFU-F and CFU-OB by in vivo bisphosphonate and fluoride treatmentsThe use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network.A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.A novel inhibitory mechanism of nitrogen-containing bisphosphonate on the activity of Cl- extrusion in osteoclasts.Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration.Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells.The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes.Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice.Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells.Alendronate inhibits VEGF expression in growth plate chondrocytes by acting on the mevalonate pathway.The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum.Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue.Specificity of the zinc(II), magnesium(II) and calcium(II) complexation by (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related 1,3-(thiazol-2-yl) and 1,3-(benzothiazol-2-yl) derivatives.Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.The effect of alendronate (Fosamax) and implant surface on bone integration and remodeling in a canine model.Nephrotic proteinuria associated with high-dose pamidronate in multiple myeloma.Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt.
P2860
Q24684244-D2BB75C7-B3BB-476E-BA86-BBD7C3741488Q26851553-4DB62D53-DA21-440F-BF46-EA06D10D0E28Q27642782-A0B1A19E-5B45-47DB-B348-01D6595E757EQ28251212-DF3CC405-11B5-41B9-8319-C5F48D2BB800Q28351578-840E2265-E7B3-4524-8F7A-6212CAAD3533Q28366607-1423B9E6-99E8-4B76-AE44-C748584EC36CQ33269187-C432F896-05C0-4B1E-8AC3-635A992929D8Q33591699-64329180-94B9-4F26-B874-D76135569FFAQ33746152-C31E3344-9D6E-4D9F-92FA-32D77AE7804BQ33786905-8EC70D6C-9D8D-4FA0-98C2-4C3DC2491556Q34523564-AEA334FD-1DD8-4868-BBE2-D5C72D955FD5Q35184299-6AA17562-7D17-48A8-903A-D5CC5934B5C9Q35949189-2B97255E-8EC3-46B5-8796-F4EA8CECABC8Q36349741-CB705633-0DC3-4404-934B-E6D2C58F6281Q36553571-441D0053-7E64-42E4-9CF5-FD783C714116Q36939677-5278659B-20FE-4B66-965A-0FADD3D53BABQ37113976-8355CA76-8862-4C3D-8BFA-BEDCE97ADF43Q37119792-1F0B45BE-6A59-4E8C-B7DC-A76F644C1484Q37147457-3AE6EA51-358C-4B51-8AB0-83F99E8E256CQ37195494-6C6FEB2F-A5A3-418E-80E9-3BB2CFD07CF7Q37493951-B2E552D6-C8D3-45E1-8DA4-024740C6E8C8Q37728428-361EE38F-A5ED-4D9B-891D-E9B068B47566Q39169911-73CEA40D-BBA4-4B2B-96D6-8D93F03027C2Q39702852-664DE8F5-C1B8-499A-8FDC-A1CBE9EDF1AEQ39818295-DADEFA4E-C787-48D0-AAE3-890DEBF4D6EEQ39851518-52D32230-B757-4116-B969-CF4FC1D828A3Q40120598-1060D2AE-B959-4669-9270-05C5451C0182Q40617031-E03E4D5D-B709-4245-B45B-AD7156BA2768Q40995448-1DF6073A-618B-466C-8595-8B3A3712A7F8Q41487882-F9D4E290-7008-4AB7-8869-163BA5E8CD17Q41988099-A090B5C3-99F4-4789-9BC3-C1298FBFCBC1Q42106848-F78EAF82-FC02-4D85-94A2-122F33854342Q42465607-F4C11D49-41C9-45BF-AAC4-0B4C108C79CFQ42467133-DB8305C1-74E9-427B-849D-2B3F3CA3FB8BQ42733035-ABF25253-43DC-46CD-BBF1-94D7725A0911Q43183249-E683BB1E-13A4-4C70-8FC1-A099358BDC30Q43216496-0052B741-120B-4B23-BD8C-BB63788F828CQ43824494-11CEF81E-68D7-4D42-9083-778B8B5B5011Q44198073-23499417-D59C-4A66-919F-73896AD7DFCDQ44559365-727470E7-07FB-4F64-B558-9A9EBE7A27E4
P2860
Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@en
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@nl
type
label
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@en
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@nl
prefLabel
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@en
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@nl
P2093
P356
P1476
Nitrogen-containing bisphospho ...... otencies in vitro and in vivo.
@en
P2093
P304
P356
10.1006/BBRC.1999.0224
P407
P577
1999-02-01T00:00:00Z