Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.
about
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)Functional MAPT haplotypes: bridging the gap between genotype and neuropathologyHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsTau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279KNeuropathologic, biochemical, and molecular characterization of the frontotemporal dementias.A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects.Hereditary frontotemporal dementia caused by Tau gene mutations.Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1ADysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic targetA network of RNA and protein interactions in Fronto Temporal Dementia.Overlap between neurodegenerative disorders.Structural determinants for alternative splicing regulation of the MAPT pre-mRNATau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?Frontotemporal lobar degeneration: current concepts in the light of recent advances.Tau mutations in neurodegenerative diseases.The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion.Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease.Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.Tau mis-splicing in the pathogenesis of neurodegenerative disorders.Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations.Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndromeRegulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10.Hyperphosphorylation-induced tau oligomersSR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutationsGlycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.Tau Proteins and Tauopathies in Alzheimer's Disease.The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.Neuropathology in the S305S tau gene mutation.A role for tau in learning, memory and synaptic plasticity.Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.New genes, new dilemmas: FTLD genetics and its implications for families.Finding MAPT Mutations in Frontotemporal Dementia and Other Tauopathies.
P2860
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P2860
Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
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2003年學術文章
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name
Mutations in the tau gene that ...... u and frontotemporal dementia.
@en
Mutations in the tau gene that ...... u and frontotemporal dementia.
@nl
type
label
Mutations in the tau gene that ...... u and frontotemporal dementia.
@en
Mutations in the tau gene that ...... u and frontotemporal dementia.
@nl
prefLabel
Mutations in the tau gene that ...... u and frontotemporal dementia.
@en
Mutations in the tau gene that ...... u and frontotemporal dementia.
@nl
P50
P356
P1433
P1476
Mutations in the tau gene that ...... u and frontotemporal dementia.
@en
P2093
Prudence M Stanford
P304
P356
10.1093/BRAIN/AWG090
P407
P50
P577
2003-04-01T00:00:00Z