Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons.
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Neurotrophins: roles in neuronal development and functionNeurotrophin-regulated signalling pathwaysA possible link between BDNF and mTOR in control of food intakeBrain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neuronsETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylationEdaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BADEthanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase.Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli.Survival activity of troglitazone in rat motoneurones.Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells.Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityOverexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's diseaseRapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expressionA simple role for BDNF in learning and memory?Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathyMicroRNA gene expression signatures in the developing neural tubeCentral amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates.RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptideNeuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathwaysRole of nerve growth factor (NGF) and its receptors in folliculogenesis.Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus.Plasticity-related genes in brain development and amygdala-dependent learning.Inhibitory Effect of Memantine on Streptozotocin-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Neurotrophic Factor Decline in Astrocytes.Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling.Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1.Characterization of insulin signaling in rat retina in vivo and ex vivo.NGF signaling in PC12 cells: the cooperation of p75(NTR) with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade.The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.Neuronal survival induced by neurotrophins requires calmodulin.Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture.Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway.
P2860
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P2860
Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Insulin receptor substrate (IR ...... red cerebral cortical neurons.
@en
Insulin receptor substrate
@nl
type
label
Insulin receptor substrate (IR ...... red cerebral cortical neurons.
@en
Insulin receptor substrate
@nl
prefLabel
Insulin receptor substrate (IR ...... red cerebral cortical neurons.
@en
Insulin receptor substrate
@nl
P2093
P356
P1476
Insulin receptor substrate (IR ...... red cerebral cortical neurons.
@en
P2093
P304
30334-30339
P356
10.1074/JBC.272.48.30334
P407
P577
1997-11-01T00:00:00Z