Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.
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PINK1 is selectively stabilized on impaired mitochondria to activate ParkinOverexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repairThe role of oxidative stress in Parkinson's diseasePharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model.Mitochondria: A Therapeutic Target for Parkinson's Disease?Mitochondrial biology and Parkinson's diseaseNovel subcellular localization for α-synuclein: possible functional consequencesMouse models of Parkinson's disease associated with mitochondrial dysfunctionThe role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelismCalcium, bioenergetics, and neuronal vulnerability in Parkinson's diseaseParkinson's disease, insulin resistance and novel agents of neuroprotectionThe three 'P's of mitophagy: PARKIN, PINK1, and post-translational modificationsMitochondrial DNA damage patterns and aging: revising the evidences for humans and miceMetabolic disturbances in diseases with neurological involvementSomatic mutations in aging, cancer and neurodegenerationMechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNAMitochondrial dysfunction and oxidative stress in Parkinson's diseaseAgeing and Parkinson's disease: why is advancing age the biggest risk factor?Mitochondrial genome changes and neurodegenerative diseasesMitochondrial involvement in neurodegenerative diseasesUpstream deregulation of calcium signaling in Parkinson's diseasePioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammationEndogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic StressMitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and agingMechanisms of mitophagyOxidative stress is not a major contributor to somatic mitochondrial DNA mutationsConverging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's diseaseParkinson's disease as a result of agingMitochondrial defects and oxidative stress in Alzheimer disease and Parkinson diseaseVariations in brain DNAThe mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stressDo mtDNA deletions drive premature aging in mtDNA mutator mice?The cybrid model of sporadic Parkinson's disease.Mitochondria: in sickness and in healthDissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle.Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxinCybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationshipsALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions.Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
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P2860
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@en
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@nl
type
label
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@en
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@nl
prefLabel
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@en
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@nl
P2093
P921
P356
P1433
P1476
Mitochondrial DNA deletions ar ...... uman substantia nigra neurons.
@en
P2093
Ann C McKee
Changiz Geula
Elena Kudryavtseva
Konstantin Khrapko
Neil W Kowall
Yevgenya Kraytsberg
P2888
P304
P356
10.1038/NG1778
P407
P577
2006-04-09T00:00:00Z