The cytoplasmic substrate permeation pathway of serotonin transporter.
about
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognitionMonoamine transporters: insights from molecular dynamics simulationsVisualizing functional motions of membrane transporters with molecular dynamics simulationsModeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsPhosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMPA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterModelling and mutational analysis of Aspergillus nidulans UreA, a member of the subfamily of urea/H⁺ transporters in fungi and plantsLigand effects on cross-linking support a conformational mechanism for serotonin transport.GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETConformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocationTransmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporterUnbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.Cytoplasmic permeation pathway of neurotransmitter transporters.Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanismsMyristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.Conformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesisThe mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transportersSodium translocation by the iminoglycinuria associated imino transporter (SLC6A20).Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transportUnifying concept of serotonin transporter-associated currentsInvolvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine TransportersTwo Na+ Sites Control Conformational Change in a Neurotransmitter Transporter HomologMechanism for alternating access in neurotransmitter transporters.Control of serotonin transporter phosphorylation by conformational state.cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake.Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori).Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.Identification of novel serotonin transporter compounds by virtual screening.An Extra Amino Acid Residue in Transmembrane Domain 10 of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Is Required for Efficient Ion-coupled Transport.
P2860
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P2860
The cytoplasmic substrate permeation pathway of serotonin transporter.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
The cytoplasmic substrate permeation pathway of serotonin transporter.
@en
The cytoplasmic substrate permeation pathway of serotonin transporter.
@nl
type
label
The cytoplasmic substrate permeation pathway of serotonin transporter.
@en
The cytoplasmic substrate permeation pathway of serotonin transporter.
@nl
prefLabel
The cytoplasmic substrate permeation pathway of serotonin transporter.
@en
The cytoplasmic substrate permeation pathway of serotonin transporter.
@nl
P2860
P356
P1476
The cytoplasmic substrate permeation pathway of serotonin transporter.
@en
P2093
Gary Rudnick
Yuan-Wei Zhang
P2860
P304
36213-36220
P356
10.1074/JBC.M605468200
P407
P577
2006-09-28T00:00:00Z