Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.
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Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunitsKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainCharacterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy.Short QT and atrial fibrillation: A KCNQ1 mutation-specific disease. Late follow-up in three unrelated children.Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationKCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillationMonogenic atrial fibrillation as pathophysiological paradigms.KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.Characterization of a Chinese KCNQ1 mutation (R259H) that shortens repolarization and causes short QT syndrome 2.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks)R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation.Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines.Structural basis for KCNE3 modulation of potassium recycling in epitheliaStructural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex.Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillationGating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.cAMP-dependent regulation of IKs single-channel kinetics.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Cardiac Delayed Rectifier Potassium Channels in Health and Disease.Molecular Pathophysiology of Congenital Long QT Syndrome.In silico investigation of a KCNQ1 mutation associated with short QT syndrome.Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation.Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling.Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.Human Atrial Arrhythmogenesis and Sinus Bradycardia in -Linked Short QT Syndrome: Insights From Computational Modelling
P2860
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P2860
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.
description
2008 nî lūn-bûn
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2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
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2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
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2008年學術文章
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2008年學術文章
@zh-hant
name
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@en
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@nl
type
label
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@en
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@nl
prefLabel
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@en
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@nl
P2093
P2860
P1476
Mechanisms by which atrial fib ...... deactivation of IKs channels.
@en
P2093
Lioara Restier
Michael C Sanguinetti
P2860
P304
P356
10.1113/JPHYSIOL.2008.157511
P407
P577
2008-07-03T00:00:00Z