Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.
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Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zincInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesAcid-base transport in pancreas-new challengesChanges in extracellular pH and myocardial ischaemia alter the cardiac effects of diadenosine tetraphosphate and pentaphosphateA mechanism of intracellular P2X receptor activation.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsMolecular determinants of proton modulation of glycine receptors.Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.Activation and regulation of purinergic P2X receptor channelsAcid-sensitive ion channels and receptorsCalcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.Allosteric modulation of ATP-gated P2X receptor channelsStructural interpretation of P2X receptor mutagenesis studies on drug actionA new role for P2X4 receptors as modulators of lung surfactant secretion.Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force.Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels.Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.Zn2+ and H+ are coactivators of acid-sensing ion channels.The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH.Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin.
P2860
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P2860
Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@en
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@nl
type
label
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@en
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@nl
prefLabel
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@en
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@nl
P2093
P2860
P1476
Mutation of histidine 286 of t ...... extracellular pH sensitivity.
@en
P2093
A R George
C D Benham
C E Clarke
H J Meadows
P2860
P304
P356
10.1111/J.1469-7793.2000.00697.X
P407
P478
P577
2000-03-01T00:00:00Z