The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH.
about
Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zincSelective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zincZinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as MetalloproteinsA histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding siteGated access to the pore of a P2X receptor: structural implications for closed-open transitions.Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsCovalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP.Cloning and characterization of a P2X receptor expressed in the central nervous system of Lymnaea stagnalisAn intersubunit zinc binding site in rat P2X2 receptorsExtended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions.Activation and regulation of purinergic P2X receptor channelsAcid-sensitive ion channels and receptorsHigh potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanismResponses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gatingAllosteric modulation of ATP-gated P2X receptor channelsContribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors.Opposite effects of zinc on human and rat P2X2 receptors.The P2X1 ion channel in platelet function.Structural interpretation of P2X receptor mutagenesis studies on drug actionP2X(7) receptor at the heart of disease.Heteromeric assembly of P2X subunits.Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.Histidines are responsible for zinc potentiation of the current in KDC1 carrot channels.A P2X7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line.Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels.Bimodal action of protons on ATP currents of rat PC12 cellsModulation of ATP-induced currents by zinc in acutely isolated hypothalamic neurons of the rat.Activation of the P2X7 ion channel by soluble and covalently bound ligands.Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons.P2X receptors in mouse Leydig cells.Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition.Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.
P2860
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P2860
The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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name
The role of histidine residues in modulation of the rat P2X
@nl
The role of histidine residues ...... ) purinoceptor by zinc and pH.
@en
type
label
The role of histidine residues in modulation of the rat P2X
@nl
The role of histidine residues ...... ) purinoceptor by zinc and pH.
@en
prefLabel
The role of histidine residues in modulation of the rat P2X
@nl
The role of histidine residues ...... ) purinoceptor by zinc and pH.
@en
P2860
P1476
The role of histidine residues ...... 2) purinoceptor by zinc and pH
@en
P2093
J Dylan Clyne
Lisa D LaPointe
P2860
P304
P356
10.1113/JPHYSIOL.2001.013244
P407
P577
2002-03-01T00:00:00Z