about
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomasK27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomasDissecting the genomic complexity underlying medulloblastomaGenome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionDriver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaEmbryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity.FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomasSubgroup-specific prognostic implications of TP53 mutation in medulloblastoma.BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal diseaseTransitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics.DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group.Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities.Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis.Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management.MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner.Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model.Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome.Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles.Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location.The landscape of genomic alterations across childhood cancers.H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers.Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma.Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.
P50
Q24339074-28EADE76-8413-407D-BACA-FDE4D893934BQ24615283-2F8F2C48-8147-4D2C-AB22-D9BBD2E62015Q24621907-960B4D7F-0C7A-4EDC-B824-BFCBAA4D3BB0Q27852966-49037420-0534-41C8-BB95-D242830AB0ADQ29616862-4D113D9D-FBBE-4515-A369-D7D156DAFF82Q33917715-692285A3-F818-4DB2-ABA5-C48B7FEBEEB2Q34215755-AC2EC22D-DD6C-45AF-9A01-7F59B7BE9CEEQ34354839-6EAB1C7A-84ED-4BFF-9AE3-A6C3BCD37C1BQ34362028-F0CE0215-E1BB-44AF-9F6F-5B85B52735DCQ34515911-80E1EA19-9EC5-4214-8529-3084ECC84D80Q34810691-77D46304-B874-4A4D-AE97-CB5795DA14ACQ36780903-090FA352-BA3A-43E8-87C7-8954B5A3E999Q36929844-DA701D4D-2114-45F0-96AA-32B9DC48D827Q37028013-3EE572F7-D126-4B81-9BEB-028F6A584AFBQ37729676-FA08D168-9B83-4BF1-AD9A-E8F99CC0F4D4Q37736041-1378E8E1-5A1F-4EF2-BA51-979A19A81477Q38123270-044C2EEF-201B-4737-A74B-50633DDA9B9CQ38743450-040E2F90-C907-494C-B715-B4652F8C3F34Q38773933-B5CA5192-AE9B-41A1-A167-1786B2848A46Q38978887-EC675993-3693-4015-AFD4-EE5C65385857Q38983942-C3E94D44-10E1-413B-827B-083FE682F17FQ39126000-91B138B0-7869-4E31-A183-5442CE2AAF50Q39391190-7ABE7B3A-5126-439B-96BF-6F4DE1C96446Q41082397-EB42F077-7FBD-4367-BB76-476455BEEE94Q41264935-76ADD54E-8EB9-4B36-827D-1B187F9BF9E4Q41827259-FC4BF1D9-BA4A-422A-A602-8691AF57E41DQ43558429-30D9E9F0-6B4B-4BD3-8483-2DC5BE058FC4Q46001867-35DBF30B-58ED-4EBA-81B3-26DDA85FBABAQ47981289-50575CD1-16ED-42F6-8CEA-E6007F8FC643Q48194323-B0238C85-D042-4A01-851F-75AE13205721Q48329991-FE092DF7-0660-4156-99EE-19AE7E5782EBQ48455596-31864FDF-B7F8-41FF-80E4-A721AD9D59A0Q48668080-B3EC3C5F-D729-4BCE-885A-711154ACE14DQ48872957-6220B5D6-6072-4D7A-A291-570C7515BB2BQ48915503-EE29C215-0D44-433E-920F-3E5475DE6067Q50089322-B504C9DA-B1B9-4079-8837-8C2900778294Q50421569-5E83E567-383D-4603-8E8B-7A40FF0B486FQ50733824-F3C9B7F4-878B-43BC-B417-A614B58FE407Q50744249-9E854792-9CFC-4290-8B7D-DF61535C0B0BQ51019249-E89E2839-9752-469C-A276-27902FF111E3
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Dominik Sturm
@ast
Dominik Sturm
@en
Dominik Sturm
@es
Dominik Sturm
@nl
Dominik Sturm
@sl
type
label
Dominik Sturm
@ast
Dominik Sturm
@en
Dominik Sturm
@es
Dominik Sturm
@nl
Dominik Sturm
@sl
prefLabel
Dominik Sturm
@ast
Dominik Sturm
@en
Dominik Sturm
@es
Dominik Sturm
@nl
Dominik Sturm
@sl
P106
P21
P31
P496
0000-0003-0250-1696
P569
2000-01-01T00:00:00Z