Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
about
Complex regulation of γ-secretase: from obligatory to modulatory subunitsChanged membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged ratsRetention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domainNicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.β-Arrestins as potential therapeutic targets for Alzheimer's disease.Investigation of deregulated genes of Notch signaling pathway in human T cell acute lymphoblastic leukemia cell lines and clinical samples.Nicastrin overexpression in transgenic mice induces aberrant behavior and APP processing.Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
P2860
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P2860
Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mutations in nicastrin protein ...... and Notch protein processing.
@en
type
label
Mutations in nicastrin protein ...... and Notch protein processing.
@en
prefLabel
Mutations in nicastrin protein ...... and Notch protein processing.
@en
P2093
P2860
P356
P1476
Mutations in nicastrin protein ...... and Notch protein processing.
@en
P2093
Annelie Pamrén
Jan Näslund
Johanna Wanngren
Lars O Tjernberg
Ratan Bhat
P2860
P304
31153-31158
P356
10.1074/JBC.C111.235267
P407
P577
2011-07-18T00:00:00Z