LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.

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DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

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LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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LRRK2 interacts with ATM and r ...... response to genotoxic stress.

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Baojie Li

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Eng King Tan

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Jing Li

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Li Zeng

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Minxia Gu

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Wei Zhang

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Zhen Cao

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Zhi Dong Zhou

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Zhongcan Chen

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P2860

DNA Damage, Aging, and Cancer

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Histone deacetylases (HDACs): characterization of the classical HDAC family

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4494-4505

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scholarly article

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10.1093/HMG/DDX337

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P478

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2017-08-29T00:00:00Z

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P698

28973420

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LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.

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LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.

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