Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
about
LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectivesmTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signalingAge-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Role of the Golgi Apparatus in the Blood-Brain Barrier: Golgi Protection May Be a Targeted Therapy for Neurological Diseases.LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradationLRRK2 dephosphorylation increases its ubiquitination.Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker.Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.The LRRK2 signalling system.LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives.Regulation of LRRK2 by Phosphatases.Molecular Insights and Functional Implication of LRRK2 Dimerization.LRRK2 Phosphorylation.Casein kinase 1α: biological mechanisms and theranostic potential.Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.
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P2860
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@ast
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en-gb
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@nl
type
label
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@ast
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en-gb
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@nl
prefLabel
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@ast
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en-gb
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@nl
P2093
P2860
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P3181
P356
P1476
Phosphorylation of LRRK2 by ca ...... ntial interaction with ARHGEF7
@en
P2093
Adamantios Mamais
Alice Kaganovich
Iakov N Rudenko
Michael A Nalls
Ravindran Kumaran
Sara Haddock
P2860
P2888
P3181
P356
10.1038/NCOMMS6827
P407
P577
2014-01-01T00:00:00Z
P5875
P6179
1045734066