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Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancerNatural Killer Cells and Liver FibrosisCYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cellsAge-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient miceDefinition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests.Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo.Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers.Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A.Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasisCluster-localized sparse logistic regression for SNP data.A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitorsIn vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data GenerationCombining transcription factor binding affinities with open-chromatin data for accurate gene expression predictionIncreased polysialic acid neural cell adhesion molecule expression in human hippocampus of heroin addicts.Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines.Lysophosphatidylethanolamine is - in contrast to - choline - generated under in vivo conditions exclusively by phospholipase A2 but not by hypochlorous acid.Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes.From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.Modeling hepatic osteodystrophy in Abcb4 deficient miceMetabolic detoxification: implications for thresholds.A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells.Optimal strategies for sequential validation of significant features from high-dimensional genomic data.Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients.Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex.Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients.Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers.Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness.Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate.Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients.Handedness and the X chromosome: the role of androgen receptor CAG-repeat lengthProfiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test batteryLineage-specific regulation of epigenetic modifier genes in human liver and brainEuropean genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.Toxicogenomics directory of chemically exposed human hepatocytes.
P50
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Jan G Hengstler
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Jan G Hengstler
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Jan G Hengstler
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Jan G Hengstler
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Jan G Hengstler
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