A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
about
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolismMitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplicationRole of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027Lidamycin shows highly potent cytotoxic to myeloma cells and inhibits tumor growth in miceGenes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus NocardiopsisFactor VII light chain-targeted lidamycin shows intensified therapeutic efficacy for liver cancer.Pharmacokinetics of C-1027 in mice as determined by TCA-RA method.Tissue distribution and excretion of 125I-lidamycin in mice and rats.Antitumor efficacy of lidamycin on hepatoma and active moiety of its moleculeDraft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein.Site-specific PEGylation of lidamycin and its antitumor activity.Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.Potential for biocontrol of melanized fungi by actinobacteria isolated from intertidal region of Ilha Do Mel, Paraná, Brazil.Synergistic inhibition of angiogenesis and glioma cell-induced angiogenesis by the combination of temozolomide and enediyne antibiotic lidamycin.Transaminases for the synthesis of enantiopure beta-amino acids.Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.
P2860
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P2860
A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh-hant
name
A new macromolecular antitumor ...... ation and biological activity.
@en
A new macromolecular antitumor ...... ation and biological activity.
@nl
type
label
A new macromolecular antitumor ...... ation and biological activity.
@en
A new macromolecular antitumor ...... ation and biological activity.
@nl
prefLabel
A new macromolecular antitumor ...... ation and biological activity.
@en
A new macromolecular antitumor ...... ation and biological activity.
@nl
P2093
P1476
A new macromolecular antitumor ...... ation and biological activity.
@en
P2093
Marunaka T
P304
P577
1988-11-01T00:00:00Z