Identification of the minimal protein domain required for priming activity of Munc13-1.
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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegansDOC2B acts as a calcium switch and enhances vesicle fusionThe presynaptic active zoneMunc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticityThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsIdentification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosisNonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.Munc13-1 is required for presynaptic long-term potentiationMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexRegulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clustersTomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapsesSynaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorderHeterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmissionActive zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1.Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.GPCR mediated regulation of synaptic transmission.Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle primingFunctional synergy between the Munc13 C-terminal C1 and C2 domains.Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.Rescuing the subprime meltdown in insulin exocytosis in diabetes.CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactionsUNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains.An evolutionarily conserved presynaptic protein is required for isoflurane sensitivity in Caenorhabditis elegans.Presynaptic long-term plasticityMolecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.CAPS and Munc13: CATCHRs that SNARE VesiclesMacromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release.Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37.ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.C2-domain containing calcium sensors in neuroendocrine secretion.Munc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosis.Munc13-1 Translocates to the Plasma Membrane in a Doc2B- and Calcium-Dependent MannerTwo distinct secretory vesicle-priming steps in adrenal chromaffin cells
P2860
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P2860
Identification of the minimal protein domain required for priming activity of Munc13-1.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Identification of the minimal protein domain required for priming activity of Munc13-1.
@en
Identification of the minimal protein domain required for priming activity of Munc13-1.
@nl
type
label
Identification of the minimal protein domain required for priming activity of Munc13-1.
@en
Identification of the minimal protein domain required for priming activity of Munc13-1.
@nl
prefLabel
Identification of the minimal protein domain required for priming activity of Munc13-1.
@en
Identification of the minimal protein domain required for priming activity of Munc13-1.
@nl
P2093
P50
P1433
P1476
Identification of the minimal protein domain required for priming activity of Munc13-1.
@en
P2093
Claudia Schirra
Nils Brose
Sonja M Wojcik
Zheng-Xing Wu
P304
P356
10.1016/J.CUB.2005.10.055
P407
P577
2005-11-03T00:00:00Z