Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. - Wikidata - awgldk - TriplyDB

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

http://www.wikidata.org/entity/Q34074906

about

Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7 Platelet signaling: a complex interplay between inhibitory and activatory networks Distinct initial SNARE configurations underlying the diversity of exocytosis Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.The nuts and bolts of the platelet release reaction.Granule-mediated release of sphingosine-1-phosphate by activated platelets.Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy.Absence of platelet phenotype in mice lacking the motor protein myosin Va Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling VAMP-7 links granule exocytosis to actin reorganization during platelet activation.Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.Munc18b/STXBP2 is required for platelet secretion.MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.Platelet secretion is kinetically heterogeneous in an agonist-responsive manner.Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2.Lysosome-related organelles: unusual compartments become mainstream.Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production.A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation.Platelet signaling-a primer.Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment.Rab27 effectors, pleiotropic regulators in secretory pathways.Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?Platelet secretion: From haemostasis to wound healing and beyond.Platelet secretory behaviour: as diverse as the granules … or not?Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Platelet secretion in inflammatory and infectious diseases.New Concepts and Mechanisms of Platelet Activation Signaling.Advances in vascular thiol isomerase function.Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.

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P2860

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

http://www.wikidata.org/entity/Q34074906

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@ast

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@en

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@nl

type

label

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@ast

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@en

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@nl

prefLabel

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@ast

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@en

Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@nl

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BLOOD-2010-02-270934

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Munc13-4 is a limiting factor ...... ranule release and hemostasis.

@en

P2093

Christian Wimmer

http://www.w3.org/2001/XMLSchema#string

Frederick M Hughson

http://www.w3.org/2001/XMLSchema#string

Michael C Chicka

http://www.w3.org/2001/XMLSchema#string

Qiansheng Ren

http://www.w3.org/2001/XMLSchema#string

Shaojing Ye

http://www.w3.org/2001/XMLSchema#string

Sidney W Whiteheart

http://www.w3.org/2001/XMLSchema#string

Yi Ren

http://www.w3.org/2001/XMLSchema#string

P2860

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion

A role for Sec1/Munc18 proteins in platelet exocytosis

Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

SNAREpins: minimal machinery for membrane fusion

Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion

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869-877

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10.1182/BLOOD-2010-02-270934

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6

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116

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2010-04-30T00:00:00Z

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43534876

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20435885

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2924225

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