Subversion of the Bcl-2 life/death switch in cancer development and therapy. - Wikidata - awgldk - TriplyDB

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

http://www.wikidata.org/entity/Q50930237

about

New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer.Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.ABT-737 synergizes with Bortezomib to kill melanoma cells.Is the focus moving toward a combination of targeted drugs?Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies ARC synergizes with ABT-737 to induce apoptosis in human cancer cells.Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas.Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737.Protein kinase A determines platelet life span and survival by regulating apoptosis.Venetoclax for the treatment of chronic lymphocytic leukemia.

P2860

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P2860

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

http://www.wikidata.org/entity/Q50930237

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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name

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@en

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@nl

type

label

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@en

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@nl

prefLabel

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@en

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

@nl

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SQB.2005.70.009

P1433

Cold Spring Harbor Laboratory. Symposia on Quantitative Biology

P1476

Subversion of the Bcl-2 life/death switch in cancer development and therapy

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P2093

Bath ML

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Chen L

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Colman P

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Fletcher JI

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Hinds M

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Kelly PN

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Kuroda J

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Smith DP

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P2860

The Hallmarks of Cancer

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

Structure of Bax: coregulation of dimer formation and intracellular localization

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

P304

469-477

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scholarly article

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10.1101/SQB.2005.70.009

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P478

70

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Andreas Strasser

Philippe Bouillet

Mark F van Delft

Hamsa Puthalakath

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2005-01-01T00:00:00Z

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16869785

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