Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.
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Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient miceIsolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets familyHepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in miceConserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix proteinNotch signaling controls multiple steps of pancreatic differentiationThe bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreasThe MafA transcription factor appears to be responsible for tissue-specific expression of insulinHormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cellsGenetically engineered mouse models of pancreatic adenocarcinomaTranscription factor regulation of pancreatic organogenesis, differentiation and maturationGhrelin cells replace insulin-producing beta cells in two mouse models of pancreas developmentpdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasisGata6 is an important regulator of mouse pancreas developmentArx is required for normal enteroendocrine cell development in mice and humansLoss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouseSOX9 is required for maintenance of the pancreatic progenitor cell poolA dosage-dependent requirement for Sox9 in pancreatic endocrine cell formationInsm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic isletThe pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomainPDX:PBX complexes are required for normal proliferation of pancreatic cells during developmentRole of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Epigenomic plasticity enables human pancreatic α to β cell reprogramming.RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium.An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).Bipotential mouse embryonic liver (BMEL) cells spontaneously express Pdx1 and Ngn3 but do not undergo further pancreatic differentiation upon Hes1 down-regulation.Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during developmentPdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells.p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expressionThe NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein bindingSox9-haploinsufficiency causes glucose intolerance in miceA recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1.Essential role of the small GTPase Ran in postnatal pancreatic islet development.A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cellsExperimental control of pancreatic development and maintenance.
P2860
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P2860
Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@en
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@nl
type
label
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@en
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@nl
prefLabel
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@en
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@nl
P2093
P1433
P1476
Expression of murine STF-1, a ...... e progenitors during ontogeny.
@en
P2093
Montminy MR
Teitelman G
P407
P577
1995-01-01T00:00:00Z