Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.
about
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsOrchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signallingHuman RAG mutations: biochemistry and clinical implicationsBood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferaseTargeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agentThe taming of the shrew: Regulation of a catalytically active domesticated transposaseDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingThe in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusionAutoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationCoupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Spatio-temporal regulation of RAG2 following genotoxic stress.The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complexCell cycle quiescence of early lymphoid progenitors in adult bone marrow.Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways.von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.IL-7 promotes T cell proliferation through destabilization of p27Kip1.NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activityATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineagePre-TCR-induced beta-catenin facilitates traversal through beta-selectionMechanisms controlling expression of the RAG locus during lymphocyte development.Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell developmentKaryopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Balancing Proliferation with Igκ Recombination during B-lymphopoiesisAllelic exclusion of immunoglobulin genes: models and mechanisms.Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis.SCFs in the new millennium.Ubiquitination events that regulate recombination of immunoglobulin Loci gene segments.Histone methylation and V(D)J recombination.Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.Novel molecular mechanism for generating NK-cell fitness and memory.
P2860
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P2860
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V
@nl
Ubiquitylation of RAG-2 by Skp ...... recombinase to the cell cycle.
@en
type
label
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V
@nl
Ubiquitylation of RAG-2 by Skp ...... recombinase to the cell cycle.
@en
prefLabel
Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V
@nl
Ubiquitylation of RAG-2 by Skp ...... recombinase to the cell cycle.
@en
P2093
P1433
P1476
Ubiquitylation of RAG-2 by Skp ...... recombinase to the cell cycle.
@en
P2093
Fu-Chung Chang
Jihyun Lee
Keiichi Nakayama
Keiko Nakayama
Stephen Desiderio
P304
P356
10.1016/J.MOLCEL.2005.05.011
P577
2005-06-01T00:00:00Z