about
Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasisThe structural basis for in situ activation of DNA alkylation by duocarmycin SAStructural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90Svetamycins A-G, Unusual Piperazic Acid-Containing Peptides from Streptomyces sp.Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella speciesTheonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.The binding mode of cladocoran A to the human group IIA phospholipase A(2).Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.Marine sponge steroids as nuclear receptor ligands.Identification and mechanism of action analysis of the new PARP-1 inhibitor 2″-hydroxygenkwanol A.2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors.Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme.Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.Anti-inflammatory trends of new benzimidazole derivatives.Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods.Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry.Cyclic Diarylheptanoids from Corylus avellana Green Leafy Covers: Determination of Their Absolute Configurations and Evaluation of Their Antioxidant and Antimicrobial Activities.Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.Flavanocoumarins from Guazuma ulmifolia bark and evaluation of their affinity for STAT1.Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei.Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity.Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans.Structure-activity relationship study of 16 a-thiocamptothecins: an integrated in vitro and in silico approach.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomainSynthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.
P50
Q27309876-D398346B-2030-4AD6-826E-8A3238990927Q27625426-E42BAA1C-99F8-4A22-944C-18E92BC2FCC2Q27649178-9B648182-2000-4417-A45C-8ED8BB20556DQ28482390-C2038CC6-F27B-4CC8-BD33-6D7FF208AF21Q32177499-716368AB-00C9-441A-9819-6FB3DED336F8Q33512059-D0DC0EDF-B9B3-42F4-B11E-3FDAB7F6D07AQ33558877-6C10B79A-DB03-45ED-A041-2CAA670D7142Q33853122-386DAA6A-9AE7-4303-AFB8-AA4E6559B09BQ33889833-44A66093-4A32-4EBA-94E5-D66A91DB0BF3Q34033380-D81F6D57-EB72-40C8-8FBC-AADAEC2C5746Q34062051-B4EF56E7-26A0-4209-BF4C-8807335F5B5CQ34195592-37ED3FB3-9357-46D1-BB01-E68A3B1D4998Q34248586-073F139E-06FC-42FD-AFB8-81206C8453C2Q34397954-DEBC1052-9661-4184-BD02-F0F6496D02F4Q34418952-F1FAEAA3-475B-4B31-88E1-0B3872F7F088Q35638858-F5697A3F-D9F6-4D99-A093-2E11449844E0Q35896365-8DB664D1-3102-4CC5-AE5D-98210F76FB64Q35936086-5DBEB657-C943-486D-936C-4F797A5D779CQ36095575-3F723611-D946-4239-AD30-AEB477125B2CQ36139722-6FEBF5D7-28D1-424B-BB20-698F42E383E2Q36890547-BE4C1576-ED0B-4DCA-BFC1-FE68A9D9FB41Q37131026-3CD40130-F9B1-4F14-B378-9D0D2E4816CBQ38777350-0C8C0D22-DBDE-4FFA-B9C0-C2BC4FF64685Q38807135-3321CBD8-9EA5-4204-858A-E1B59531D37BQ38912429-19DBC849-0F4C-4ABB-AC0F-1871BAFC8FD0Q38983803-176CDB7A-7D89-4215-804F-7768F25005A7Q38998719-20123166-497E-4360-ABF4-3FE719A01317Q39131450-B679A12F-A6FA-4D53-B96B-99F4F3C592D1Q39243688-8931C512-4120-4A57-91CE-4C8506CBFF06Q39325184-4BF0C29F-B221-4086-A6AD-F6685E2ADC9FQ39435827-6896BB3C-78B5-473A-98F2-97CFA22E9AF1Q39541247-142E1AFF-7E58-4726-AD03-55089B5E3A0AQ39591833-35C40902-AB3E-4367-B5EF-DC7CDF681B12Q39622510-BEF02F6E-55C5-41B5-BFC5-3808264E21FDQ39631427-8D8FE8E7-461A-451B-85C3-488EB736CC00Q39633195-E6B27E04-785C-479D-82AE-C8D4D1A91860Q39809867-27DE0B0C-A491-412F-A77A-8A994D9D024AQ39846240-67FD32ED-251D-41DF-9658-B3691108D6EDQ39864415-E106A220-21A2-4BED-A9D5-8BA0B6041BB0Q39977733-A4EA74CD-DB37-408D-8A5A-1FFE4D924C5A
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Giuseppe Bifulco
@ast
Giuseppe Bifulco
@en
Giuseppe Bifulco
@es
Giuseppe Bifulco
@nl
Giuseppe Bifulco
@sl
type
label
Giuseppe Bifulco
@ast
Giuseppe Bifulco
@en
Giuseppe Bifulco
@es
Giuseppe Bifulco
@nl
Giuseppe Bifulco
@sl
prefLabel
Giuseppe Bifulco
@ast
Giuseppe Bifulco
@en
Giuseppe Bifulco
@es
Giuseppe Bifulco
@nl
Giuseppe Bifulco
@sl
P106
P21
P31
P496
0000-0002-1788-5170