Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.
about
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunitsThe KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interactionO-glycosylation of the cardiac I(Ks) complexRole of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heartKv7.1 surface expression is regulated by epithelial cell polarizationIntracellular domains interactions and gated motions of I(KS) potassium channel subunitsDynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2CaMKII regulation of cardiac K channelsStructure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-Helix Complex Provides Insight into M Current ModulationHigh incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance.KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity.Novel CALM3 mutations in pediatric long QT syndrome patients support a CALM3-specific calmodulinopathy.Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering.Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1Kv7 channels can function without constitutive calmodulin tetheringKCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.Calcium and arrhythmogenesis.Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk.Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical DisordersCoupling of voltage-sensors to the channel pore: a comparative viewAn inactivation gate in the selectivity filter of KCNQ1 potassium channels.Structural insights into neuronal K+ channel-calmodulin complexes.The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.Secondary structure of a KCNE cytoplasmic domainModifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics.Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ ChannelsCalmodulin and CaMKII as molecular switches for cardiac ion channels.Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks)A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels.Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias.The C-terminus of Kv7 channels: a multifunctional module.PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.Tethering chemistry and K+ channels.Calmodulin mutations associated with recurrent cardiac arrest in infants.
P2860
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P2860
Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Calmodulin is essential for ca ...... function in long-QT mutations.
@en
Calmodulin is essential for ca ...... function in long-QT mutations.
@nl
type
label
Calmodulin is essential for ca ...... function in long-QT mutations.
@en
Calmodulin is essential for ca ...... function in long-QT mutations.
@nl
prefLabel
Calmodulin is essential for ca ...... function in long-QT mutations.
@en
Calmodulin is essential for ca ...... function in long-QT mutations.
@nl
P2093
P1433
P1476
Calmodulin is essential for ca ...... function in long-QT mutations.
@en
P2093
Asher Peretz
Bernard Attali
Joel Hirsch
Liora Shamgar
Olaf Pongs
Reuven Wiener
P304
P356
10.1161/01.RES.0000218979.40770.69
P577
2006-03-23T00:00:00Z