Temperature dependence of human ether-a-go-go-related gene K+ currents.
about
Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesFever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome.Optical mapping of the electrical activity of isolated adult zebrafish hearts: acute effects of temperature.A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncopeThe S1 helix critically regulates the finely tuned gating of Kv11.1 channelsHigh temperature sensitivity is intrinsic to voltage-gated potassium channels.Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation.The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of actionModels of HERG gatingKinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.A molecular framework for temperature-dependent gating of ion channelsMechanism of block of the hERG K+ channel by the scorpion toxin CnErg1Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.Endocytic control of ion channel density as a target for cardiovascular disease.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K+ channel properties.NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels.The hERG K(+) channel S4 domain L532P mutation: characterization at 37°CEffects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 ChannelsA temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.Toward a New Gold Standard for Early Safety: Automated Temperature-Controlled hERG Test on the PatchLiner.Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel.Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.Regulation of the voltage-insensitive step of HERG activation by extracellular pH.Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.
P2860
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P2860
Temperature dependence of human ether-a-go-go-related gene K+ currents.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@en
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@nl
type
label
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@en
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@nl
prefLabel
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@en
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@nl
P2093
P2860
P1476
Temperature dependence of human ether-a-go-go-related gene K+ currents.
@en
P2093
Anthony Varghese
Christopher L-H Huang
Jane A Bursill
Martyn P Mahaut-Smith
P2860
P304
P356
10.1152/AJPCELL.00596.2005
P577
2006-02-01T00:00:00Z