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Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural AnalysisCrystallization of bi-functional ligand protein complexesCombining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studiesX-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitorsN-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic ActivityDiscovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV InhibitorsDiscovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell modelsSynthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR)Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 InhibitorsSynthesis and HIV-1 inhibitory properties of new tetrahydrobenzoquinazolinedione and tetrahydrobenzocycloheptenuracil derivatives and of their thioxo analoguesIn vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitorsMatrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues.Multicomponent mixtures for cryoprotection and ligand solubilization.Targeting ADAM17 Sheddase Activity in Cancer.ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors.Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors.Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption.Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells.Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity.New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing.Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions.Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activationNovel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.Synthesis and inhibitory activity towards human leukocyte elastase of new 7alpha-methoxy and 7alpha-chloro (2-acyloxymethyl) cephem derivatives.Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Armando Rossello
@ast
Armando Rossello
@en
Armando Rossello
@es
Armando Rossello
@nl
Armando Rossello
@sl
type
label
Armando Rossello
@ast
Armando Rossello
@en
Armando Rossello
@es
Armando Rossello
@nl
Armando Rossello
@sl
prefLabel
Armando Rossello
@ast
Armando Rossello
@en
Armando Rossello
@es
Armando Rossello
@nl
Armando Rossello
@sl
P1053
C-5803-2014
P106
P1153
7004655378
P21
P31
P3829
P496
0000-0002-6795-8091