Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
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UVB-induced apoptosis drives clonal expansion during skin tumor developmentProtein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vectorEnhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic miceEarly onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenTargeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.Animal models of psoriasis.Keratinocyte apoptosis in epidermal development and disease.Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.PLCε signaling in cancer.Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome.Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3'-untranslated region.Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations.Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.Proliferation, apoptosis, and survivin expression in keratinocytic neoplasms and hyperplasias.Restrained Terminal Differentiation and Sustained Stemness in Neonatal Skin by Ha-Ras and Bcl-2.Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death.Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes.
P2860
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P2860
Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@en
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@nl
type
label
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@en
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@nl
prefLabel
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@en
Human keratin-1.bcl-2 transgen ...... tible to skin tumor formation.
@nl
P2093
P356
P1433
P1476
Human keratin-1.bcl-2 transgen ...... ptible to skin tumor formation
@en
P2093
Greenhalgh D
McDonnell TJ
Rodríguez-Villanueva J
P2888
P304
P356
10.1038/SJ.ONC.1201610
P407
P577
1998-02-01T00:00:00Z