Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.
about
Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationHyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filamentsTau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tauPolymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer diseaseFunctional implications of glycogen synthase kinase-3-mediated tau phosphorylationRoles of AMP-activated protein kinase in Alzheimer's disease.Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletionAlzheimer disease therapeutics: focus on the disease and not just plaques and tanglesActivation of the 5'-AMP-Activated Protein Kinase in the Cerebral Cortex of Young Senescence-Accelerated P8 Mice and Association with GSK3β- and PP2A-Dependent Inhibition of p-tau₃₉₆ Expression.The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.Tau and neurodegenerative disease: the story so far.Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study.Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration.Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation.The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.Phosphorylation-dependent monoclonal Tau antibodies do not reliably report phosphorylation by extracellular signal-regulated kinase 2 at specific sites.
P2860
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P2860
Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@en
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@nl
type
label
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@en
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@nl
prefLabel
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@en
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@nl
P2093
P2860
P1433
P1476
Rapid Alzheimer-like phosphory ...... ent protein kinases and GSK-3.
@en
P2093
P2860
P304
P356
10.1016/0014-5793(94)01445-7
P407
P577
1995-01-01T00:00:00Z