Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.
about
The hitchhiker's guide to the voltage-gated sodium channel galaxyStructural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIAUltra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleVoltage-dependent membrane displacements measured by atomic force microscopyFolding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatusSynergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.Molecular motions within the pore of voltage-dependent sodium channelsPore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Neurotoxins and their binding areas on voltage-gated sodium channels.The free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain.Structure and function of voltage-gated sodium channels.Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movementsMechano-electrical transduction: new insights into old ideas.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Interaction of the BKCa channel gating ring with dendrotoxins.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment.Interaction between the pore and a fast gate of the cardiac sodium channel.mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.Immobilizing the moving parts of voltage-gated ion channelsElectrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.Trans-channel interactions in batrachotoxin-modified rat skeletal muscle sodium channels: kinetic analysis of mutual inhibition between mu-conotoxin GIIIA derivatives and amine blockersTrans-channel interactions in batrachotoxin-modified skeletal muscle sodium channels: voltage-dependent block by cytoplasmic amines, and the influence of mu-conotoxin GIIIA derivatives and permeant ionsMapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins.Mechanisms of cation permeation in cardiac sodium channel: description by dynamic pore model.Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels.Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA.Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIICThe selectivity filter of the voltage-gated sodium channel is involved in channel activation.Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets.Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity.
P2860
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P2860
Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Interactions between a pore-bl ...... approach to channel geometry.
@en
Interactions between a pore-bl ...... approach to channel geometry.
@nl
type
label
Interactions between a pore-bl ...... approach to channel geometry.
@en
Interactions between a pore-bl ...... approach to channel geometry.
@nl
prefLabel
Interactions between a pore-bl ...... approach to channel geometry.
@en
Interactions between a pore-bl ...... approach to channel geometry.
@nl
P2093
P1433
P1476
Interactions between a pore-bl ...... approach to channel geometry.
@en
P2093
Kularatna AS
Prusak-Sochaczewski E
P304
P356
10.1016/S0896-6273(00)80058-6
P407
P577
1996-02-01T00:00:00Z