Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
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Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticityCooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformationThe R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195 † ‡Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutantReplacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability,Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand bindingDesign, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitorsPromotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyXAnalysis of mRNA recognition by human thymidylate synthase.Chemical shift imprint of intersubunit communication in a symmetric homodimer.Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.
P2860
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P2860
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
description
1994 nî lūn-bûn
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1994年の論文
@ja
1994年学术文章
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1994年学术文章
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1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
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1994年学术文章
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1994年學術文章
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1994年學術文章
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name
Mode of binding of folate anal ...... ctive substrate binding sites.
@en
Mode of binding of folate anal ...... ctive substrate binding sites.
@nl
type
label
Mode of binding of folate anal ...... ctive substrate binding sites.
@en
Mode of binding of folate anal ...... ctive substrate binding sites.
@nl
prefLabel
Mode of binding of folate anal ...... ctive substrate binding sites.
@en
Mode of binding of folate anal ...... ctive substrate binding sites.
@nl
P2093
P1476
Mode of binding of folate anal ...... active substrate binding sites
@en
P2093
P304
P407
P577
1994-01-01T00:00:00Z