Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice.
about
Customizing the genome as therapy for the β-hemoglobinopathiesMaking sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genomeThe CRISPR revolution and its impact on cancer researchCRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in miceExome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.Using CRISPR/Cas to study gene function and model disease in vivoSomatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.Precision cancer mouse models through genome editing with CRISPR-Cas9.Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesisA versatile reporter system for CRISPR-mediated chromosomal rearrangements.DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAsEfficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.The CRISPR road: from bench to bedside on an RNA-guided path.Animal Models Are Valid to Uncover Disease Mechanisms.CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.Non-coding genetic variants in human disease.Functional interrogation of non-coding DNA through CRISPR genome editing.Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos.Chromosome engineering in zygotes with CRISPR/Cas9.A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchMup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysisMicroinjection-based generation of mutant mice with a double mutation and a 0.5 Mb deletion in their genome by the CRISPR/Cas9 system.Efficient and rapid generation of large genomic variants in rats and mice using CRISMEREConnecting genotypes, phenotypes and fitness: harnessing the power of CRISPR/Cas9 genome editing.Organoid technologies meet genome engineering.CRISPR/CAS9 Technologies.Modeling human disease in rodents by CRISPR/Cas9 genome editing.Correction of the Exon 2 Duplication in DMD Myoblasts by a Single CRISPR/Cas9 System.Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies in Drosophila.Formation of new chromatin domains determines pathogenicity of genomic duplications.Generation of megabase-scale deletions, inversions and duplications involving the Contactin-6 gene in mice by CRISPR/Cas9 technology.The three-dimensional genome: regulating gene expression during pluripotency and development.Genome editing for the reproduction and remedy of human diseases in mice.A Transgenic Core Facility's Experience in Genome Editing Revolution.CRISPR/Cas9 Genome Editing in Embryonic Stem Cells.Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.In vivo genome editing thrives with diversified CRISPR technologies.
P2860
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P2860
Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@en
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@nl
type
label
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@en
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@nl
prefLabel
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@en
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@nl
P2093
P50
P1433
P1476
Deletions, Inversions, Duplica ...... ants using CRISPR/Cas in Mice.
@en
P2093
Anja J Will
Izabela Harabula
Lars Wittler
Marina Borschiwer
Sinje Geuer
Stefan Mundlos
Wing Lee Chan
P356
10.1016/J.CELREP.2015.01.016
P50
P577
2015-02-04T00:00:00Z