Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
about
Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control regionErythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control regionMolecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essentialGenomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10pLocus control regionsSorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotypeCurrent and future alternative therapies for beta-thalassemia majorThe human beta-globin locus control regionEmbryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell culturesDevelopmental regulation of DNA replication timing at the human beta globin locus.Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.The impact of local genome sequence on defining heterochromatin domains.Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Neighbourhood continuity is not required for correct testis gene expression in Drosophila.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionThe locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Potential use of genetically modified pigs as organ donors for transplantation into humans.DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceErythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family.Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.Dividing the empire: boundary chromatin elements delimit the territory of enhancers.Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Long-range control of gene expression: emerging mechanisms and disruption in disease.Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region.A new element within the T-cell receptor alpha locus required for tissue-specific locus control region activityHypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophilaStructural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementTransgene repeat arrays interact with distant heterochromatin and cause silencing in cis and transEfficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.Evolution of hemoglobin and its genesA cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regenerationCooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencingActive genes dynamically colocalize to shared sites of ongoing transcription.Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world.Development of a macromolecular diffusion pathway in the lens.
P2860
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P2860
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@en
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@nl
type
label
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@en
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@nl
prefLabel
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@en
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@nl
P2093
P1433
P1476
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
@en
P2093
Grosveld F
Langeveld A
Strouboulis J
Trimborn T
Wijgerde M
Yannoutsos N
P304
P356
10.1016/S0092-8674(00)81327-6
P407
P577
1996-10-01T00:00:00Z