Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.
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Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic miceTranscriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceFunctional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease.The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes.The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.Histone acetylation at the human beta-globin locus changes with developmental age.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci.Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster.The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Locus control region mediated regulation of adult beta-globin gene expression.Deletion of the human beta-globin LCR 5'HS4 or 5'HS1 differentially affects beta-like globin gene expression in beta-YAC transgenic mice.Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters.A mechanism for Ikaros regulation of human globin gene switching.
P2860
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P2860
Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Synergistic and additive prope ...... or LCR chromatin architecture.
@ast
Synergistic and additive prope ...... or LCR chromatin architecture.
@en
type
label
Synergistic and additive prope ...... or LCR chromatin architecture.
@ast
Synergistic and additive prope ...... or LCR chromatin architecture.
@en
prefLabel
Synergistic and additive prope ...... or LCR chromatin architecture.
@ast
Synergistic and additive prope ...... or LCR chromatin architecture.
@en
P2093
P2860
P1476
Synergistic and additive prope ...... or LCR chromatin architecture.
@en
P2093
George Stamatoyannopoulos
Kenneth R Peterson
Patrick A Navas
Ping Xiang
Qiliang Li
Xiangdong Fang
P2860
P304
P356
10.1128/MCB.25.16.7033-7041.2005
P407
P577
2005-08-01T00:00:00Z