Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion
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Locus control regionsSystematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiationThe human beta-globin locus control regionQuantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCRMi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic miceMutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.Control of globin gene expression during development and erythroid differentiationTranscriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementGenome architecture of the human beta-globin locus affects developmental regulation of gene expressionPromoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Autonomous silencing as well as competition controls gamma-globin gene expression during development.Beta-globin locus control region HS2 and HS3 interact structurally and functionallyFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes.The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsDefinitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globinDeletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesThe hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.Epigenetic modifications and chromosome conformations of the beta globin locus throughout development.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitroTranscriptional mechanisms underlying hemoglobin synthesis.Current status of globin gene therapy for the treatment of beta-thalassaemia.Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes.Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I.Role of NF-Y in in vivo regulation of the gamma-globin geneThe polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.The roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.Deletion of the human beta-globin LCR 5'HS4 or 5'HS1 differentially affects beta-like globin gene expression in beta-YAC transgenic mice.
P2860
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P2860
Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Developmental specificity of t ...... mice with an HS3 core deletion
@ast
Developmental specificity of t ...... mice with an HS3 core deletion
@en
type
label
Developmental specificity of t ...... mice with an HS3 core deletion
@ast
Developmental specificity of t ...... mice with an HS3 core deletion
@en
prefLabel
Developmental specificity of t ...... mice with an HS3 core deletion
@ast
Developmental specificity of t ...... mice with an HS3 core deletion
@en
P2093
P2860
P356
P1476
Developmental specificity of t ...... mice with an HS3 core deletion
@en
P2093
E Skarpidi
G Stamatoyannopoulos
K R Peterson
P2860
P304
P356
10.1128/MCB.18.7.4188
P407
P577
1998-07-01T00:00:00Z