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Checkpoint signaling from a single DNA interstrand crosslinkDNA Sequence Modulates the Conformation of the Food Mutagen 2-Amino-3-methylimidazo[4,5- f ]quinoline in the Recognition Sequence of the Nar I Restriction Enzyme † , ‡Structure of the 1, N 2 -Etheno-2′-deoxyguanosine Lesion in the 3′-G(εdG)T-5′ Sequence Opposite a One-Base DeletionMinor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1, N 2 -γ-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage,Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequenceBase-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) within the NarI recognition sequence.The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro.In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG."One-pot" syntheses of malondialdehyde adducts of nucleosides.Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivoBase-Displaced Intercalated Conformation of the 2-Amino-3-methylimidazo[4,5-f]quinoline N(2)-dG DNA Adduct Positioned at the Nonreiterated G(1) in the NarI Restriction Site.Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IVCharacterization of nitrogen mustard formamidopyrimidine adduct formation of bis(2-chloroethyl)ethylamine with calf thymus DNA and a human mammary cancer cell lineDNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cellsNovel genomic island modifies DNA with 7-deazaguanine derivativesSite-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.Chemical and electrochemical oxidation of C8-arylamine adducts of 2'-deoxyguanosineSynthesis of the four stereoisomers of 2,3-epoxy-4-hydroxynonanal and their reactivity with deoxyguanosine.Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic SitesTranslesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one.DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal.Translesion Synthesis of the N(2)-2'-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1.1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine.Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N(5)-methyl formamidopyrimidine adduct in primate cells.Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases.Simplified synthesis of individual stereoisomers of the 4-hydroxynonenal adducts of deoxyguanosineSynthesis and characterization of oligonucleotides containing a nitrogen mustard formamidopyrimidine monoadduct of deoxyguanosine.Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6.Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2.DNA interchain cross-links formed by acrolein and crotonaldehyde.Site-specific mutagenicity of stereochemically defined 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells.Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine.
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description
chemist
@en
onderzoeker
@nl
հետազոտող
@hy
name
Carmelo J Rizzo
@ast
Carmelo J Rizzo
@es
Carmelo J Rizzo
@nl
Carmelo J Rizzo
@sl
Carmelo J. Rizzo
@en
type
label
Carmelo J Rizzo
@ast
Carmelo J Rizzo
@es
Carmelo J Rizzo
@nl
Carmelo J Rizzo
@sl
Carmelo J. Rizzo
@en
prefLabel
Carmelo J Rizzo
@ast
Carmelo J Rizzo
@es
Carmelo J Rizzo
@nl
Carmelo J Rizzo
@sl
Carmelo J. Rizzo
@en
P106
P21
P31
P496
0000-0001-9005-611X