Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
about
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.Gut microbiota derived metabolites in cardiovascular health and disease.Redox Biology of Respiratory Viral InfectionsAdvancements in Host-Based Interventions for Influenza TreatmentNrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogrammingTMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expressionModulating Iron for Metabolic Support of TB Host DefenseCircadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2The Human SLC1A5 (ASCT2) Amino Acid Transporter: From Function to Structure and Role in Cell BiologyResolution of chronic inflammatory disease: universal and tissue-specific conceptsMicroenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studiesTargeting T Cell Metabolism for Improvement of Cancer Immunotherapy
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P2860
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
description
2018 nî lūn-bûn
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2018年の論文
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2018年学术文章
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2018年学术文章
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2018年学术文章
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2018年学术文章
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2018年学术文章
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2018年学术文章
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2018年學術文章
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name
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@en
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@nl
type
label
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@en
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@nl
prefLabel
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@en
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
@nl
P2093
P2860
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P356
P1154
2-s2.0-85045147264
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
@en
P2093
Anne F McGettrick
Daniel C Sévin
Deepthi Menon
Dina Dikovskaya
Dylan G Ryan
Edward T Chouchani
Elena V Knatko
Evanna L Mills
Gino Brunori
Hiran A Prag
P2860
P2888
P304
P356
10.1038/NATURE25986
P407
P50
P5530
P577
2018-03-28T00:00:00Z
P6179
1101795549