about
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenaseDysregulated metabolism contributes to oncogenesisA roadmap for interpreting (13)C metabolite labeling patterns from cellsSerine is a natural ligand and allosteric activator of pyruvate kinase M2Defects in mitochondrial metabolism and cancerOncometabolites: Unconventional triggers of oncogenic signalling cascadesOPA1 controls apoptotic cristae remodeling independently from mitochondrial fusionA novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in functionMetabolic profiling of hypoxic cells revealed a catabolic signature required for cell survivalPredicting selective drug targets in cancer through metabolic networksMitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelingCell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Designing a broad-spectrum integrative approach for cancer prevention and treatment.Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells.Fumarate induces redox-dependent senescence by modifying glutathione metabolism.Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis.Predicting selective drug targets in cancer through metabolic networks.Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death.Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas.Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilitiesIdentification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications.HIF-independent role of prolyl hydroxylases in the cellular response to amino acidsMitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiencyMetabolic determinants of the immune modulatory function of neural stem cellsMitochondria in cancer: not just innocent bystanders.Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transitionA three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.Inborn and acquired metabolic defects in cancer.From tumor prevention to therapy: empowering p53 to fight back.The role of mitochondria in the oncogenic signal transduction.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christian Frezza
@ast
Christian Frezza
@en
Christian Frezza
@es
Christian Frezza
@nl
Christian Frezza
@sl
type
label
Christian Frezza
@ast
Christian Frezza
@en
Christian Frezza
@es
Christian Frezza
@nl
Christian Frezza
@sl
altLabel
Christian Frezza
@en
prefLabel
Christian Frezza
@ast
Christian Frezza
@en
Christian Frezza
@es
Christian Frezza
@nl
Christian Frezza
@sl
P1053
G-2174-2010
P106
P1153
6505487116
P21
P31
P3762
P3829
P3835
christian-frezza2
P496
0000-0002-3293-7397