Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. - Wikidata - awgldk - TriplyDB

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.

http://www.wikidata.org/entity/Q53061352

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Cellular ageing mechanisms in osteoarthritis Role of autophagy in chronic kidney diseases Inflammation and intracellular metabolism: new targets in OA Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis Review: Metabolic Regulation of Inflammation in Osteoarthritis mTOR: a potential therapeutic target in osteoarthritis?Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1 Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis.MicroRNA-29a Counteracts Synovitis in Knee Osteoarthritis Pathogenesis by Targeting VEGF.MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis.The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.Emerging targets in osteoarthritis therapy.The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes.17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways.Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins.Ageing and the pathogenesis of osteoarthritis.Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration.Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.Recent developments in emerging therapeutic targets of osteoarthritis.Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy.High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature.The role of metabolism in the pathogenesis of osteoarthritis.Autophagy: controlling cell fate in rheumatic diseases.Degenerative Joint Diseases and Neuroinflammation.Tackling chondrocyte hypertrophy with multifunctional nanoparticles.BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.Rapamycin Maintains the Chondrocytic Phenotype and Interferes with Inflammatory Cytokine Induced Processes.Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation.Targeting oxidative stress to reduce osteoarthritis.PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis.PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.Identification of genes and pathways in the synovia of women with osteoarthritis by bioinformatics analysis.

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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.

http://www.wikidata.org/entity/Q53061352

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Cartilage-specific deletion of ...... ects mice from osteoarthritis.

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Cartilage-specific deletion of ...... ects mice from osteoarthritis.

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Cartilage-specific deletion of ...... ects mice from osteoarthritis.

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ANNRHEUMDIS-2013-204599

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Annals of the Rheumatic Diseases

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Cartilage-specific deletion of ...... ects mice from osteoarthritis.

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Bertrand Lussier

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David Lagares

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Faezeh Vasheghani

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Kayla Simeone

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Meryem Blati

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Mohit Kapoor

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Peter Roughley

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Yue Zhang

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P2860

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Mammalian autophagy: core molecular machinery and signaling regulation

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

Autophagy fights disease through cellular self-digestion

Upstream and downstream of mTOR

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Autophagy and the integrated stress response

The role of autophagy during the early neonatal starvation period

The role of the Atg1/ULK1 complex in autophagy regulation

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1432-1440

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10.1136/ANNRHEUMDIS-2013-204599

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7

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260997656

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